Tetrahedron

The synthesis of substituted phenols from pyranone precursors

LJ Marshall, KM Cable, NP Botting

Index: Marshall, Laura J.; Cable, Karl M.; Botting, Nigel P. Tetrahedron, 2009 , vol. 65, # 39 p. 8165 - 8170

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Citation Number: 10

Abstract

The syntheses of various substituted phenols from pyranone precursors, namely 4H-pyran-4- one, 3-(benzyloxy)-2-methyl-4H-pyran-4-one (benzyl-maltol), 2, 6-dimethyl-4H-pyran-4-one and diethyl 4-oxo-4H-pyran-2, 6-dicarboxylate (diethyl chelidonate) are presented. A variety of pronucleophiles were used in combination with tert-butanol as solvent and potassium tert- butoxide as base, using conventional heating methods and microwave conditions.