Synthesis and chemical reactivity of indenoisoxazoles

TL Lemke, KN Sawhney…

Index: Lemke, Thomas L.; Sawhney, Kailash N.; Lemke, B. Kaye Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 363 - 368

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Citation Number: 10

Abstract

Abstract Treatment of 2-pivaloyl-1, 3-indandione (1) with hydroxylamine under acidic conditions, results in formation of 8-t-butylindeno [1, 2-c] isoxazol-7-one (2) while treatment of the triketone with hydroxylamine at neutral or basic pH gave 6 which upon cyclization gave the isomeric 3-t-butylindeno [1, 2-c] isoxazol-4-one (7). Compound 7 was readily reduced to amine 12 by treatment with hydrazine or hydrogen over platinum. The amine, ...