Regioselective oxidation of cholic acid and its 7β epimer by using o-iodoxybenzoic acid
PS Dangate, CL Salunke, KG Akamanchi
Index: Dangate, Prasad S.; Salunke, Chetan L.; Akamanchi, Krishnacharya G. Steroids, 2011 , vol. 76, # 12 p. 1397 - 1399
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Citation Number: 4
Abstract
Rational exploration directed by DFT (density functional theory) based atomic Fukui indices, lead to development of regioselective oxidation of cholic acid and its 7β epimer by o- iodoxybenzoic acid. In case of cholic acid only, 7α-hydroxyl underwent oxidation, where as in its 7β epimer the selectivity was towards 12α-hydroxy group. Since these oxidations are the key steps in synthesis of ursodeoxycholic acid starting from cholic acid these findings ...
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