Synthesis, biological evaluation and 2D-QSAR analysis of benzoxazoles as antimicrobial agents

…, B Tekiner-Gulbas, K Bolelli, O Temiz-Arpaci…

Index: Ertan, Tugba; Yildiz, Ilkay; Tekiner-Gulbas, Betul; Bolelli, Kayhan; Temiz-Arpaci, Ozlem; Ozkan, Semiha; Kaynak, Fatma; Yalcin, Ismail; Aki, Esin European Journal of Medicinal Chemistry, 2009 , vol. 44, # 2 p. 501 - 510

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Citation Number: 62

Abstract

A new series of 5 (or 6)-nitro/amino-2-(substituted phenyl/benzyl) benzoxazole derivatives (1a–1m, 2a–2l) were synthesized and evaluated for antibacterial and antifungal activities against Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli, Candida albicans and their drug-resistant isolate. Microbiological results indicated that the synthesized compounds possessed a broad ...

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