SYNTHESIS AND DISCOVERY OF NEW BISADDUCTS DERIVED FROM HETEROCYCLIC ALDEHYDES AND ACTIVE METHYLENE COMPOUNDS AS …

M Asad, CW Oo, RS Kumar, H Osman…

Index: Asad, Mohammad; Oo, Chuan-Wei; Kumar, Raju Suresh; Osman, Hasnah; Ali, Andmohamed Ashraf Acta Poloniae Pharmaceutica - Drug Research, 2013 , vol. 70, # 2 p. 221 - 228

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Abstract

Abstract: A series of some new bisadducts possessing five, six membered and coumarin subunits were synthesized by the condensation of heterocyclic aldehydes with active methylene compounds and characterized by IR, NMR and X-ray crystallographic studies and were assayed as antitubercular agents. Among the bisadducts, 4-hydroxy-3-[(4-hydroxy- 2-oxo-2H-3-chromenyl)(3-thienyl) methyl]-2H-2-chromenone 3a was found to be the most ...