Decomposition of 1-(ω-aminoalkanoyl) guanidines under alkaline conditions

A Brennauer, M Keller, M Freund, G Bernhardt…

Index: Brennauer, Albert; Keller, Max; Freund, Matthias; Bernhardt, Guenther; Buschauer, Armin Tetrahedron Letters, 2007 , vol. 48, # 39 p. 6996 - 6999

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Citation Number: 14

Abstract

The decomposition of some NG-(ω-aminoalkanoyl) argininamides, which are key intermediates for the preparation of radiolabeled and fluorescent neuropeptide Y receptor ligands, prompted us to synthesize a small series of simple 1-(ω-aminoalkanoyl) guanidines, and to investigate these model compounds for stability in alkaline buffers. The degradation of acylguanidines was monitored by time resolved UV spectroscopy. The most labile ...