Regioselective synthesis of 3-aryl substituted pyrrolidines via palladium catalyzed arylation: pharmacological evaluation for central dopaminergic and serotonergic …

…, MW Smith, K Svensson, A Carlsson, N Waters

Index: Sonesson, Clas; Wikstroem, Hakan; Smith, Martin W.; Svensson, Kjell; Carlsson, Arvid; Waters, Nicholas Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 3 p. 241 - 246

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Citation Number: 25

Abstract

A series of 3-arylpyrrolidines has been synthesised via palladium catalyzed arylation and evaluated for dopaminergic and serotonergic activity in vitro and in vivo. Compounds substituted by electron withdrawing groups on the meta position of the aromatic ring, were found to be preferential dopamine autoreceptor antagonists.