A novel one-pot synthesis of 7-methoxy-2-arylthieno [3, 2-b] pyridine-3-ols in domino fashion
S Puvvala, VD Jadhav, SM Farooq, B Patro…
Index: Puvvala, Srinu; Jadhav, Vinod D.; Farooq, Sheikh M.; Patro, Balaram; Reddy, Ch. Venkata Ramana Tetrahedron Letters, 2013 , vol. 54, # 37 p. 5043 - 5047
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Abstract
Abstract A simple and efficient synthesis of 7-methoxy-2-arylthieno [3, 2-b] pyridine-3-ols was achieved using a novel one-pot LDA-promoted domino reaction. Although this class of compounds are not very well represented in the literature, similar skeletons are of immense biological importance. A few closely related compounds are reported with multi-step syntheses using harsh conditions and longer reaction time.
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