Synthesis and biological evaluation of a novel structural type of serotonin 5-HT 3 receptor antagonists

RV Perumal, R Mahesh

Index: Venkatesha Perumal, Ramachandran; Mahesh, Radhakrishnan Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 10 p. 2769 - 2772

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Citation Number: 24

Abstract

A series of novel 3-substituted quinoxalin-2-carboxamides were designed as per the pharmacophoric requirement for 5-HT3 receptor antagonists and prepared by microwave irradiation and also by conventional method. The compounds were characterized by spectral data (IR, 1H NMR, and MS) and the purity was ascertained by microanalysis. The synthesized compounds were evaluated for 5-HT3 antagonisms in longitudinal muscle- ...