Tetrahedron Letters

Microwave-enhanced bismuth triflate-catalyzed epoxide opening with aliphatic amines

T Ollevier, E Nadeau

Index: Ollevier, Thierry; Nadeau, Etienne Tetrahedron Letters, 2008 , vol. 49, # 9 p. 1546 - 1550

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Citation Number: 33

Abstract

In the presence of a catalytic amount of Bi (OTf) 3· 4H2O and under microwave irradiation, neat mixtures of epoxides and amines afforded smoothly the corresponding 2-amino alcohols. A wide variety of aliphatic amines were reacted with cycloalkene oxide, styrene oxide, and stilbene oxide. The reaction proceeded rapidly and afforded the 2-amino alcohols in high up to quantitative yields. All products could be obtained without aqueous ...

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