Synthesis and histamine H2 agonistic activity of arpromidine analogues: replacement of the pheniramine-like moiety by non-heterocyclic groups

…, A Friese-Kimmel, G Baumann, W Schunack

Index: Buschauer, A; Friese-Kimmel A; Baumann, G; Schunack, W European Journal of Medicinal Chemistry, 1992 , vol. 27, # 4 p. 321 - 330

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Citation Number: 25

Abstract

Abstract Analogues of the potent histamine H 2 agonist arpromidine, characterized by non- heterocyclic groups (phenyl, cyclohexyl, alkyl) instead of the pheniramine-like portion, were prepared and tested for their H 2 agonistic and H 1 antagonistic activity in the isolated guinea pig right atrium and ileum, respectively. In the diphenylpropylguanidine series an increase in H 2 agonistic potency resulted from mono-or difluorination at one or both ...