N, N-diethyl-(R)-[3-(2-aminopropyl)-1 h-indol-7-yloxy] acetamide: Its process chemistry ranging from enantiocontrolled construction of the chiral amine side chain to …

…, S Kato, D Sugimori, Y Yamada

Index: Ishiyama, Kazunao; Yamada, Yasuhiro Tetrahedron Letters, 2005 , vol. 46, # 6 p. 1021 - 1022

Full Text: HTML

Citation Number: 4

Abstract

To access N, N-diethyl-(R)-[3-(2-aminopropyl)-1 H-indol-7-yloxy] acetamide (3), a key intermediate for AJ-9677 (2) acting as a potent and selective agonist for β3-adrenergic receptors, the (R)-configured 2-aminopropyl side chain of 3 is elaborated in three distinct