Alkyl, unsaturated,(hetero) aryl, and N-protected α-amino ketones by acylation of organometallic reagents

…, KNB Le, L Khelashvili, PP Mohapatra

Index: Katritzky, Alan R.; Le, Khanh N. B.; Khelashvili, Levan; Mohapatra, Prabhu P. Journal of Organic Chemistry, 2006 , vol. 71, # 26 p. 9861 - 9864

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Citation Number: 51

Abstract

Stable and easily accessible N-acylbenzotriazoles, derived from a variety of aliphatic, unsaturated,(hetero) aromatic, and N-protected α-amino carboxylic acids, were reacted with Grignard and heteroaryllithium reagents to afford corresponding ketones in good to excellent yields.