One step synthesis of 2-hydroxymethylisoflavone and their osteogenic activity

M Kumar, P Rawat, J Kureel, AK Singh, D Singh…

Index: Kumar, Manmeet; Rawat, Preeti; Kureel, Jyoti; Singh, Anuj Kumar; Singh, Divya; Maurya, Rakesh Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 6 p. 1706 - 1709

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Citation Number: 5

Abstract

An efficient one step synthesis of new 2-hydroxymethylisoflavone is reported. A series of deoxybenzoin was subjected to cyclization with glyoxal in the presence of basic condition (KOH/EtOH) to afford the 2-hydroxymethyl isoflavone. The structures of compounds 5a–g were confirmed by NMR experiments including 1H, 13C, HMBC, HSQC and COSY. These compounds were assessed for stimulation of osteoblast function using primary culture of ...

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One step synthesis of 2-hydroxymethylisoflavone and their osteogenic activity

Abstract

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