Tetrahedron letters

A practical stereoselective synthesis of (2S, 4S)-4-tert-butoxycarbonylamino-2-methylpyrrolidine

…, K Raye, A Claiborne, L Seif, B Macri, JJ Plattner

Index: Qun, Li; Chu, Daniel T. W.; Raye, Kathleen; Claiborne, Akiyo; Seif, Louis; Macri, Bryan; Plattner, Jacob J. Tetrahedron Letters, 1995 , vol. 36, # 46 p. 8391 - 8394

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Citation Number: 12

Abstract

Two practical syntheses of (2S, 4S)-4-tert-butoxycarbonylamino-2-methylpyrrolidine, an important intermediate for quinolone antibacterial agents, have been developed through the combination of diastereo and enantioselective reactions starting from ethyl crotonate and L- alanine, respectively.

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