Total synthesis of nigellicine and nigeglanine hydrobromide

EL Elliott, SM Bushell, M Cavero, B Tolan…

Index: Elliott, Eric L.; Bushell, Simon M.; Cavero, Marta; Tolan, Brian; Kelly, T. Ross Organic Letters, 2005 , vol. 7, # 12 p. 2449 - 2451

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Citation Number: 28

Abstract

The tricyclic pyridazino[1,2-a]indazolium ring system is rarely encountered. Apart from being the subject of one patent, 1 it has appeared in the literature only in the context of three natural products. The first member of the family, nigellicine (1), was isolated in 1985 from the seeds of Nigella sativa. 2 Subsequently, two additional alkaloids containing the same ring system, nigeglanine (2) and nigellidine (3), were isolated from Nigella glandulifera 3 and Nigella sativa, 4 ...