Metal halide hydrates as lewis acid catalysts for the conjugated friedel-crafts reactions of indoles and activated olefins

CS Schwalm, MA Ceschi, D Russowsky

Index: Schwalm, Cristiane S.; Ceschi, Marco Antonio; Russowsky, Dennis Journal of the Brazilian Chemical Society, 2011 , vol. 22, # 4 p. 623 - 636

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Citation Number: 21

Abstract

ABSTRACT Metal halide hydrates such as SnCl 2· 2H 2 O, MnCl 2· 4H 2 O, SrCl 2· 6H 2 O, CrCl 2· 6H 2 O, CoCl 2· 6H 2 O e CeCl 3· 7H 2 O were investigated as mild Lewis acids catalysts for the conjugate Friedel-Crafts reaction between indoles and activated olefins. The reactions were carried out with aliphatic unsaturated ketones over a period of days at room temperature, while chalcones reacted only under reflux conditions. The reactions with ...