Modulating the development of E. coli biofilms with 2-aminoimidazoles

…, RW Huigens, SA Rogers, C Melander

Index: Reed, Catherine S.; Huigens III, Robert W.; Rogers, Steven A.; Melander, Christian Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 21 p. 6310 - 6312

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Citation Number: 31

Abstract

The synthesis of a 20 member 2-aminoimidazole/triazole pilot library is reported. Each member of the library was screened for its ability to inhibit or promote biofilm development of either Escherichia coli and Acinetobacter baumannii. From this screen, E. coli-selective 2- aminoimidazoles were discovered, with the best inhibitor inhibiting biofilm development with an IC50 of 13μM. The most potent promoter of E. coli biofilm formation promoted biofilm ...