Organic letters

Photolysis of diacyl peroxides: A radical-based approach for the synthesis of functionalized amino acids

MD Spantulescu, RP Jain, DJ Derksen…

Index: Spantulescu, M. Daniel; Jain, Rajendra P.; Derksen, Darren J.; Vederas, John C. Organic Letters, 2003 , vol. 5, # 16 p. 2963 - 2965

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Citation Number: 28

Abstract

Photolysis of the amino acid derived symmetrical and unsymmetrical diacyl peroxides at 254 nm at low temperature (-78 to-196° C) generates various bis (amino acids) in a concise manner and with orthogonal protection. The methodology was applied to the synthesis of (4 R)-5-propyl-l-leucine (PrLeu), a component of HUN-7293.

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