Biarylpropylsulfonamides as novel, potent potentiators of 2-amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)-propanoic acid (AMPA) receptors

…, JP Tizzano, D Bleakman, A Mandelzys…

Index: Ornstein; Zimmerman; Arnold; Bleisch; Cantrell; Simon; Zarrinmayeh; Baker; Gates; Tizzano; Bleakman; Mandelzys; Jarvie; Ho; Deverill; Kamboj Journal of Medicinal Chemistry, 2000 , vol. 43, # 23 p. 4354 - 4358

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Citation Number: 69

Abstract

Introduction. Glutamic acid is the major excitatory neurotransmitter in the central nervous system, exerting its actions at multiple subtypes of excitatory amino acid (EAA) receptors. 1 2- Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl) propanoic acid (AMPA) receptors are a subtype of the ligand gated ion channel (ionotropic) family of EAA receptors, which may be composed of assemblies of four different receptor protein subunits, GluR1-4. 2 In addition, ...