Heme oxygenase inhibition by 2-oxy-substituted 1-(1H-imidazol-1-yl)-4-phenylbutanes: effect of halogen substitution in the phenyl ring

G Roman, JG Riley, JZ Vlahakis, RT Kinobe…

Index: Roman, Gheorghe; Riley, John G.; Vlahakis, Jason Z.; Kinobe, Robert T.; Brien, James F.; Nakatsu, Kanji; Szarek, Walter A. Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 9 p. 3225 - 3234

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Citation Number: 55

Abstract

A series of 2-oxy-substituted 1-(1H-imidazol-1-yl)-4-phenylbutanes comprising imidazole– ketones, imidazole–dioxolanes, and imidazole–alcohols substituted with halogens in the phenyl ring were synthesized and evaluated as novel inhibitors of heme oxygenase which are structurally distinct from metalloporphyrins. The entire library of compounds was found to be highly active, with the bromine-and iodine-substituted derivatives being the most potent ...