High affinity surface binding of a strongly dimerizing vancomycin-group antibiotic to a model of resistant bacteria

…, SW O'Brien, A Hopkinson, DH Williams

Index: O'Brien, Dominic P.; Entress, Richard M. H.; Cooper, Matthew A.; O'Brien, Simon W.; Hopkinson, Andrew; Williams, Dudley H. Journal of the American Chemical Society, 1999 , vol. 121, # 22 p. 5259 - 5265

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Citation Number: 28

Abstract

The factors that give rise to binding enhancements when a strongly dimerizing vancomycin- group antibiotic (chloroeremomycin) binds to a model cell surface of vancomycin-resistant enterococci (VRE) have been semiquantitated. The model cell surface is comprised of vesicles to which have been anchored cell wall precursor analogues of vancomycin- resistant bacteria (which terminate in-d-lactate) via a hydrophobic docosanoyl (C22) chain ...