Conformationally Constrained Aliphatic-Aromatic Amino-Acid-Conjugated Hybrid Foldamers with Periodic β-Turn Motifs

D Srinivas, R Gonnade, S Ravindranathan…

Index: Baruah, Pranjal K.; Sreedevi; Gonnade, Rajesh; Ravindranathan, Sapna; Damodaran, Krishnan; Hofmann, Hans-Joerg; Sanjayan, Gangadhar J. Journal of Organic Chemistry, 2007 , vol. 72, # 2 p. 636 - 639

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Citation Number: 34

Abstract

In this note, we describe the design, synthesis, and structural studies of novel hybrid foldamers derived from Aib-Pro-Adb building blocks that display repeat β-turn structure motif. The foldamer having a conformationally constrained aliphatic-aromatic amino acid conjugate adopts a well-defined, compact, three-dimensional structure, governed by a combined conformational restriction imposed by the individual amino acids with which it is ...