4-Methyl-3-(arylsulfonyl) furoxans: a new class of potent inhibitors of platelet aggregation

R Calvino, R Fruttero, D Ghigo, A Bosia…

Index: Calvino, R.; Fruttero, R.; Ghigo, D.; Bosia, A.; Pescarmona, G. P.; Gasco, A. Journal of Medicinal Chemistry, 1992 , vol. 35, # 17 p. 3296 - 3300

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Citation Number: 41

Abstract

A series of 4-methyl-3-(arylthio) furoxans were synthesized by oxidation of l-(arylthio)-2- methylglyoxymes with dinitrogen tetroxide. Reduction with trimethyl phosphite of the furoxan derivatives afforded the corresponding furazans, while oxidation with an equimolar amount of 30% hydrogen peroxide in acetic acid or with an excess of 81% hydrogen peroxide in trifluoroacetic acid afforded the corresponding arylsulfinyl and arylsulfonyl analogues, ...