An acetal group suitable for the protection of 2′-hydroxy functions in rapid oligoribonucleotide synthesis

CB Reese, HT Serafinowska, G Zappia

Index: Reese, Colin B.; Serafinowska, Halina T.; Zappia, Giovanni Tetrahedron Letters, 1986 , vol. 27, # 20 p. 2291 - 2294

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Citation Number: 70

Abstract

The 1-[(2-chloro-4-methyl)phenyl]-4-methoxypiperidin-4-yl [Ctmp, as in ( )] has an acid lability similar to that of the 4-methoxytetrahydropyran-4-yl (Mthp) protecting group under mild hydrolytic conditions [pH 2–3]; however, under the relatively more drastic conditions required for the complete removal of a 9-phenylxanthen-9-yl (Px) group, the Ctmp protecting group remains virtually intact. ... The 1-[(2-chloro-4-methyl)phenyl]-4-methoxypiperidin-4-yl [Ctmp; as in ( )] ...