A tandem enzyme reaction to produce optically active halohydrins, epoxides and diols

JHL Spelberg, JET van Hylckama Vlieg, T Bosma…

Index: Lutje Spelberg, Jeffrey H.; Van Hylckama Vlieg, Johan E. T.; Bosma, Tjibbe; Kellogg, Richard M.; Janssen, Dick B. Tetrahedron Asymmetry, 1999 , vol. 10, # 15 p. 2863 - 2870

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Citation Number: 104

Abstract

The recombinant halohydrin dehalogenase from Agrobacterium radiobacter AD1 was used to obtain enantiomerically pure halohydrins and epoxides by kinetic resolution. By adding an excess of the recombinant epoxide hydrolase from the same organism the reversible conversion was drawn to completion. Halohydrins such as (S)-2, 3-dichloro-1-propanol (E> 100) and (S)-2-chloro-1-phenylethanol (E= 73) were obtained with an enantiomeric ...

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