Chroman/catechol hybrids: synthesis and evaluation of their activity against oxidative stress induced cellular damage
M Koufaki, E Theodorou, D Galaris…
Index: Koufaki, Maria; Theodorou, Elissavet; Galaris, Dimitrios; Nousis, Lambros; Katsanou, Efrosini S.; Alexis, Michael N. Journal of Medicinal Chemistry, 2006 , vol. 49, # 1 p. 300 - 306
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Citation Number: 46
Abstract
Three series of chromans substituted at positions 2 or 5 by catechol derivatives were synthesized, and their activity against oxidative stress induced cellular damage was studied. Specifically, the ability of the new molecules to protect cultured cells from H2O2-induced DNA damage was evaluated using single cell gel electrophoresis (comet assay), while the neuroprotective activity of the new compounds against oxidative stress induced ...
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