Isotope labeled 'HEA Moiety'in the synthesis of labeled HIV??protease inhibitors–Part 1

IV Ekhato, Y Liao, M Plesescu

Index: Ekhato, I. Victor; Liao, Yuan; Plesescu, Mihaela Journal of Labelled Compounds and Radiopharmaceuticals, 2004 , vol. 47, # 12 p. 821 - 835

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Citation Number: 5

Abstract

Abstract [(S)-1′-((N-tert-Butyloxycarbonyl) amino)-2S-[2 H 5] phenyl-ethyl] oxirane 11, made from [2 H 5]-bromobenzene, was transformed into the HIV-protease inhibitors [2 H 5]- DPH 153893 and [2 H 5]-DPH 140662. Both compounds are members of the hydroxyethylamine class of protease inhibitors (HIV-PIs). The method of synthesis is applicable to members of this class and the HEE group of HIV-PIs. Copyright© 2004 John ...

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