A New Tool in Peptide Engineering: A Photoswitchable Stilbene??type β??Hairpin Mimetic

M Erdélyi, A Karlén, A Gogoll

Index: Erdelyi, Mate; Karlen, Anders; Gogoll, Adolf Chemistry - A European Journal, 2006 , vol. 12, # 2 p. 403 - 412

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Citation Number: 38

Abstract

Abstract Peptide secondary structure mimetics are important tools in medicinal chemistry, as they provide analogues of endogenous peptides with new physicochemical and pharmacological properties. The development, synthesis, photochemical investigation, and conformational analysis of a stilbene-type β-hairpin mimetic capable of light-triggered conformational changes have been achieved. In addition to standard spectroscopic ...