Tetrahedron

N-benzhydryl-glycolamide esters (OBg esters) as carboxyl protecting groups in pept1de synthesis

M Amblard, M Rodriguez, J Martinez

Index: Amblard, Muriel; Rodriguez, Marc; Martinez, Jean Tetrahedron, 1988 , vol. 44, # 16 p. 5101 - 5108

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Citation Number: 24

Abstract

N-Benzhydryl-glycolamide esters (OBg esters) of various N-protected amino acids have been synthesized. In order to demonstrate their usefulness in peptide chemistry, the syntheses of For-Met-Leu-Phe-OH (chemiotactic peptide) and Pro-Leu-Gly-NH2 (MIF) have been carried out. OBg esters are compatible with commonly used protecting groups and are cleanly and selectively removed in mild alkaline conditions without any side reaction, ...

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