α-Chymotrypsin-catalysed peptide synthesis using activated esters as acyl donors

…, M Nishikawa, K Imagawa, R Yanagihara…

Index: Miyazawa, Toshifumi; Nakajo, Shin'ichi; Nishikawa, Miyako; Imagawa, Kiwamu; Yanagihara, Ryoji; Yamada, Takashi Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 24 p. 2867 - 2868

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Citation Number: 9

Abstract

The coupling efficiency in α-chymotrypsin-catalysed peptide synthesis is greatly improved by the use of activated esters such as the 2, 2, 2-trifluoroethyl ester as acyl donor instead of the conventional methyl ester; this approach is useful for the incorporation of non-protein amino acids into peptides.

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