Canadian Journal of Chemistry

A mild, general preparation of N-acyl aziridines and 2-substituted 4 (S)-benzyloxazolines

GS Bates, MA Varelas

Index: Bates, Gordon S.; Varelas, Michael A. Canadian Journal of Chemistry, 1980 , vol. 58, p. 2562 - 2566

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Citation Number: 38

Abstract

The conversion of a wide range of carboxylic acids into their acyl imidazolides with subsequent addition of an aziridine rapidly gives a quantitative yield of the corresponding N- acyl aziridines. Iodide (or bromide) ion catalysed rearrangement of N-acyl 2 (S)- benzylaziridines 1 to oxazolines 6 proceeds quantitatively.