Chemical Communications

Asymmetric synthesis of 2-substituted pyrrolidines by addition of Grignard reagents to γ-chlorinated N-tert-butanesulfinyl imine

LR Reddy, M Prashad

Index: Reddy, Leleti Rajender; Prashad, Mahavir Chemical Communications, 2010 , vol. 46, # 2 p. 222 - 224

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Citation Number: 38

Abstract

A highly diastereoselective addition of various Grignard reagents to chiral γ-chlorinated N- tert-butanesulfinyl imine resulting in the formation of 2-substituted pyrrolidines is reported. This method is general and also efficient for the preparation of both enantiomers of 2-aryl, 2- alkyl and 2-vinyl substituted pyrrolidines in high yields.