Deracemization of secondary alcohols through a concurrent tandem biocatalytic oxidation and reduction

CV Voss, CC Gruber, W Kroutil

Index: Voss, Constance V.; Gruber, Christian C.; Kroutil, Wolfgang Angewandte Chemie - International Edition, 2008 , vol. 47, # 4 p. 741 - 745

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Citation Number: 101

Abstract

The aim to obtain a highly valuable enantiomerically pure product in 100% yield and with 100% ee from a cheap racemic substrate in a one-pot process is currently a hot topic in one- pot multiple catalysis.[1, 2] In one-pot sequential catalysis, the reaction conditions can be adjusted for each step; however, concurrent catalysis is more demanding: The steps must be balanced carefully to ensure that the catalytic processes run at comparable rates and, ...

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