Synthesis and anti-angiogenesis activity of coumarin derivatives

S Lee, K Sivakumar, WS Shin, F Xie, Q Wang

Index: Lee, Seokjoon; Sivakumar, Krishnamoorthy; Shin, Woon-Seob; Xie, Fang; Wang, Qian Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 17 p. 4596 - 4599

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Citation Number: 106

Abstract

A series of 7-diethylaminocoumarin compounds were synthesized and the cytotoxicities were tested against human umbilical vein endothelial cell (HUVEC) and some cancer cells. We found that the introduction of cyano groups at the 4-position will promote the bioactivity. In particular, compounds 9 and 10 strongly inhibited the proliferation of various cancer cell lines, and 12 and 15 showed a high selectivity for HUVEC. Therefore, these coumarin ...

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