Reactions of 3, 6-bis (aminoxymethyl)-2, 5-piperazinedione with acid and alkali. Kinetic study

JL Miller, FC Neuhaus, FO Lassen…

Index: Miller,J.L. et al. Journal of Organic Chemistry, 1968 , vol. 33, # 10 p. 3908 - 3913

Full Text: HTML

Citation Number: 13

Abstract

Reaction of I with Aqueous Base. Materials.(+)-3, 6-Bis-(aminoxymethyl)-2, 5- piperazinedione (I).-To 5.41 g (0.045 mol) of D-cycloserine in a 500-ml round-bottomed flask equipped with a reflux condenser and drying tube was added 250 ml of absolute ethanol, and the mixture was stirred magnetically. Glacial acetic acid (10.3 ml) was then added, and the suspension was refluxed for 45 min. The white flocculent solid was removed by ...