Potent inhibitors of the hepatitis C virus NS3 protease: design and synthesis of macrocyclic substrate-based β-strand mimics

…, C Grand-Maître, M Poirier, B Simoneau…

Index: Goudreau, Nathalie; Brochu, Christian; Cameron, Dale R.; Duceppe, Jean-Simon; Faucher, Anne-Marie; Ferland, Jean-Marie; Grand-Maitre, Chantal; Poirier, Martin; Simoneau, Bruno; Tsantrizos, Youla S. Journal of Organic Chemistry, 2004 , vol. 69, # 19 p. 6185 - 6201

Full Text: HTML

Citation Number: 72

Abstract

The virally encoded NS3 protease is essential to the life cycle of the hepatitis C virus (HCV), an important human pathogen causing chronic hepatitis, cirrhosis of the liver, and hepatocellular carcinoma. The design and synthesis of 15-membered ring β-strand mimics which are capable of inhibiting the interactions between the HCV NS3 protease enzyme and its polyprotein substrate will be described. The binding interactions between a macrocyclic ...