Biphasic Glycerol/2??MeTHF, Ruthenium??Catalysed Enantioselective Transfer Hydrogenation of Ketones Using Sodium Hypophosphite as Hydrogen Donor

…, E Métay, N Duguet, M Lemaire

Index: Guyon, Carole; Metay, Estelle; Duguet, Nicolas; Lemaire, Marc European Journal of Organic Chemistry, 2013 , # 24 p. 5439 - 5444

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Citation Number: 7

Abstract

Abstract Sodium hypophosphite has been used as an efficient hydrogen donor in the transfer hydrogenation of aliphatic and aromatic ketones in the presence of [RuCl 2 (p- cymene)] 2 and 2, 2′-bipyridine in water. The corresponding alcohols were isolated in moderate to excellent yields (39–95%). Good chemoselectivity was observed with ester, nitrile and halide functionalities in the ketones not being reduced. An enantioselective ...