New and efficient RCM in pyridinic series: synthesis of 2H-dihydropyrano-or 2, 3H-dihydrooxepino [3, 2-b] pyridines

E Banaszak, C Comoy, Y Fort

Index: Banaszak, Estelle; Comoy, Corinne; Fort, Yves Tetrahedron Letters, 2006 , vol. 47, # 35 p. 6235 - 6238

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Citation Number: 17

Abstract

A new and very efficient route to polycyclic heterocycles with isosteric replacement of benzene by pyridine is reported. This strategy involving the RCM reaction in pyridinic series as a keystep allows us to prepare 2H-dihydropyrano-or 2, 3H-dihydrooxepino [3, 2-b] pyridines 1 and 2 in very good overall yields (47% and 44%, respectively).