Iodoaryl analogs of dioctanoylglycerol and 1-oleoyl-2-acetylglycerol as probes for protein kinase C

…, RU Simpson, KL Leach, RE Counsell

Index: Strawn; Martell; Simpson; Leach; Counsell Journal of Medicinal Chemistry, 1989 , vol. 32, # 9 p. 2104 - 2110

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Citation Number: 11

Abstract

Analogues of dioctanoylglycerol (diCs) and 1-oleoyl-2-acetylglycerol (OAG) containing an iodoaryl group have been synthesized and shown to compete with [3H] phorbol dibutyrate ([3H] PDBu) for binding to protein kinase C in a crude rat brain preparation. Phorbol diesters have been shown to bind specifically to protein kinase C and the PDBu receptor has been copurified with protein kinase C activity. All three diacylglycerol analogues were ...