Journal of medicinal chemistry

Totally Synthetic Steroid Hormones. V. 1 (±)-2, 3-Dimethoxyestra-1, 3, 5 (10)-trien-17β-ol and Some Congeners

GH Douglas, CR Walk, H Smith

Index: Douglas,G.H. et al. Journal of Medicinal Chemistry, 1966 , vol. 9, p. 27 - 29

Full Text: HTML

Citation Number: 7

Abstract

We2 have demonstrated the flexibility of our recently described tot'al syntheses of estrone3 by their extension to a variety of related 13P-alkylgonanes. This paper describes a further application to compounds of the (*)-2, 3-dimethoxyestra-l, 3, 5 (10)-triene series which were required for biological evaluation. The project seemed worthwhile in view of the occurrence of 2-methoxyestrone as a metabolite of estradiol in man. 4 The 6, 7-dimethoxy-l-tetralone ( ...

Related Articles:

Utilization of the Intramolecular Cycloaddition-Cationic π-Cyclization of an Isomünchnone Derivative for the Synthesis of (±)-Lycopodine

[Padwa; Brodney; Marino J.P.; Sheehan Journal of Organic Chemistry, 1997 , vol. 62, # 1 p. 78 - 87]

Intramolecular regioselective insertion into unactivated prochiral carbon-hydrogen bonds with diazoacetates of primary alcohols catalyzed by chiral dirhodium (II) …

[Bode; Doyle; Protopopova; Zhou Journal of Organic Chemistry, 1996 , vol. 61, # 26 p. 9146 - 9155]

Hydrogenolysis of the cyclopropyl group into an isopropyl group in the presence of a platinum catalyst and hydrobromic acid

[Fujii, Hideaki; Okada, Kayoko; Ishihara, Marina; Hanamura, Shinichi; Osa, Yumiko; Nemoto, Toru; Nagase, Hiroshi Tetrahedron, 2009 , vol. 65, # 51 p. 10623 - 10630]

Olefin saturation and acid reduction of 3, 4-dimethoxycinnamic acid and derivatives by Phanerochaete chrysosporium

[Enoki, Akio; Yajima, Yasuo; Gold, Michael H. Phytochemistry (Elsevier), 1981 , vol. 20, # 6 p. 1543 - 1546]

Cobalt (II) Chloride Hexahydrate-Diisopropylamine Catalyzed Mild and Chemoselective Reduction of Carboxylic Esters with Sodium Borohydride

[Jagdale, Arun R.; Paraskar, Abhimanyu S.; Sudalai, Arumugam Synthesis, 2009 , # 4 p. 660 - 664]

More Articles...