Preparation and biological effects of N-tris (hydroxymethyl) methylaminocarbonylmethyl derivatives of heterocyclic bases

…, A Holý, J Veselý, G Wagner

Index: Pischel; Holy; Vesely; Wagner Collection of Czechoslovak Chemical Communications, 1984 , vol. 49, # 11 p. 2541 - 2550

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Citation Number: 6

Abstract

Abstract The title compounds were synthetized by the reaction of TRIS with p-nitrophenyl or alkyl esters of N-carboxymethyl derivatives of uracil, 5-chloro-, 5-bromo-, 5-iodouracil, thymine, cytosine, 6-azauracil, 2-pyridone, 2-pyrimidone, 3-pyridazone and orotic acid. The following novel N-carboxymethyl derivatives are also described: 6-azauracil derivative VIIa by condensation of 4-thio-6-azauracil with methyl bromoacetate followed by hydrolysis, 5- ...