Synthesis of 3, 3′-Di-O-methyl Ardimerin and Exploration of Its DNA Binding Properties

…, K Ng, H Panesar, A Yepremyan, TG Minehan

Index: Yepremyan, Akop; Minehan, Thomas G. Organic and Biomolecular Chemistry, 2012 , vol. 10, # 27 p. 5194 - 5196

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Abstract

The 3, 3′-di-O-methyl derivative (15) of the bis-C-aryl glycoside natural product ardimerin (1) has been synthesized in 11 steps from 2, 3, 4, 6-tetrabenzylglucose (2) and 1, 2, 3- trimethoxybenzene (3). Key steps in the synthesis involve a Lewis acid mediated Friedel–

Solvent-free Heck-Jeffery reactions under ball-milling conditions applied to the synthesis of unnatural amino acids precursors and indoles

[Tullberg, Erik; Schacher, Felix; Peters, Dan; Frejd, Torbjoern Synthesis, 2006 , # 7 p. 1183 - 1189]

An efficient access to (R)-and (S)-6, 6′-dimethoxy-2, 2′-diiodo-1, 1′-biphenyl

[Cereghetti, Marco; Schmid, Rudolf; Schoenholzer, Peter; Rageot, Alain Tetrahedron Letters, 1996 , vol. 37, # 30 p. 5343 - 5346]

Synthesis of 3, 3′-Di-O-methyl Ardimerin and Exploration of Its DNA Binding Properties

Abstract

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