The design and synthesis of water-soluble analogues of CB30865, a quinazolin-4-one-based antitumor agent

V Bavetsias, LA Skelton, F Yafai, F Mitchell…

Index: Bavetsias; Skelton; Yafai; Mitchell; Wilson; Allan; Jackman Journal of Medicinal Chemistry, 2002 , vol. 45, # 17 p. 3692 - 3702

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Citation Number: 36

Abstract

4-[N-[7-Bromo-2-methyl-4-oxo-3, 4-dihydroquinazolin-6-ylmethyl]-N-(prop-2-ynyl) amino]-N- (3-pyridylmethyl) benzamide (CB30865) is a quinazolin-4-one antitumor agent whose high growth-inhibitory activity (W1L2 IC50= 2.8±0.50 nM) is believed to have a folate- independent locus of action. In addition, CB30865 represents a class of compounds with unique biochemical characteristics such as a delayed, non-phase specific, cell-cycle ...