Responsive MR-imaging probes for N-methyl-D-aspartate receptors and direct visualisation of the cell-surface receptors by optical microscopy

N Sim, S Gottschalk, R Pal, J Engelmann, D Parker…

Index: Sim, Neil; Gottschalk, Sven; Pal, Robert; Engelmann, Joern; Parker, David; Mishra, Anurag Chemical Science, 2013 , vol. 4, # 8 p. 3148 - 3153

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Citation Number: 10

Abstract

A series of N-methyl-d-aspartate (NMDA) receptor-targeted MRI contrast agents has been developed, based on the known competitive NMDA antagonist, 3, 4-diamino-3-cyclobutene- 1, 2-dione. Their use as responsive MR imaging probes has been evaluated in vitro and two contrast agents showed 170–176% enhancements in