ATP-citrate lyase as a target for hypolipidemic intervention. Design and synthesis of 2-substituted butanedioic acids as novel, potent inhibitors of the enzyme

…, A Shaw, D McNair, R Novelli, CE Novelli…

Index: Gribble, Andrew D.; Dolle, Roland E.; Shaw, Antony; McNair, David; Novelli, Riccardo; Novelli, Christine E.; Slingsby, Brian P.; Shah, Virendra P.; Tew, David; Saxty, Barbara A.; Allen, Mark; Groot, Pieter H.; Pearce, Nigel; Yates, John Journal of Medicinal Chemistry, 1996 , vol. 39, # 18 p. 3569 - 3584

Full Text: HTML

Citation Number: 25

Abstract

ATP-citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Inhibitors of the enzyme represent a potentially novel class of hypolipidemic agent, which are anticipated to have combined hypocholesterolemic and hypotriglyceridemic properties. A series of 2-substituted butanedioic acids have been designed and synthesized as inhibitors of the enzyme. The best compounds, 58, 68, 71, ...

Related Articles:

Sulfur Heterocycles from the Ring Closure of Bisarylalkyl Disulfides1, 2

[Campaigne,E.; Heaton,B.G. Journal of Organic Chemistry, 1964 , vol. 29, p. 2372 - 2378]

Polymer??Supported Ionic Liquids: Imidazolium Salts as Catalysts for Nucleophilic Substitution Reactions Including Fluorinations

[Kim, Dong Wook; Chi, Dae Yoon Angewandte Chemie - International Edition, 2004 , vol. 43, # 4 p. 483 - 485]

Cell-permeable and plasma-stable peptidomimetic inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction

[Bach, Anders; Eildal, Jonas N. N.; Stuhr-Hansen, Nicolai; Deeskamp, Rasmus; Gottschalk, Marie; Pedersen, Soren W.; Kristensen, Anders S.; Stromgaard, Kristian Journal of Medicinal Chemistry, 2011 , vol. 54, # 5 p. 1333 - 1346]

Sulfur Heterocycles from the Ring Closure of Bisarylalkyl Disulfides1, 2

[Campaigne,E.; Heaton,B.G. Journal of Organic Chemistry, 1964 , vol. 29, p. 2372 - 2378]

Sulfur Heterocycles from the Ring Closure of Bisarylalkyl Disulfides1, 2

[Campaigne,E.; Heaton,B.G. Journal of Organic Chemistry, 1964 , vol. 29, p. 2372 - 2378]

More Articles...