Receptor binding sites of hypoglycemic sulfonylureas and related [(acylamino) alkyl] benzoic acids

GR Brown, AJ Foubister

Index: Brown, George R.; Foubister, Alan J. Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 79 - 81

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Citation Number: 62

Abstract

(9) WC Bowman and MJ Rand," Textbook of Pharmacology", 2nd ed., Blackwell Scientific Publications, Oxford, 1980, p 19.58. thus prepared, 14-18, which either could not be metabolized to carboxyl or the conversion would be slow. None of these close analogues of the methyl compound 13 was active, suggesting that metabolic transformation of the methyl group was a prerequisite for hypoglycemic activity. The potent hypoglycemic3 acid 7 may ...