Arylsulfonamide CB2 receptor agonists: SAR and optimization of CB2 selectivity

…, JE Jenkins, B Noya-Marino, ML Brewer…

Index: Ermann, Monika; Riether, Doris; Walker, Edward R.; Mushi, Innocent F.; Jenkins, James E.; Noya-Marino, Beatriz; Brewer, Mark L.; Taylor, Malcolm G.; Amouzegh, Patricia; East, Stephen P.; Dymock, Brian W.; Gemkow, Mark J.; Kahrs, Andreas F.; Ebneth, Andreas; Loebbe, Sabine; O'Shea, Kathy; Shih, Daw-Tsun; Thomson, David Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 5 p. 1725 - 1729

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Citation Number: 36

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A high-throughput screening campaign resulted in the discovery of a highly potent dual cannabinoid receptor 1 (CB1) and 2 (CB2) agonist. Following a thorough SAR exploration, a series of selective CB2 full agonists were identified. ... A high-throughput screening campaign resulted in ...