Study of chemoselective asymmetric hydrogenation of (1-bromo-1-alkenyl) boronic esters with iridium–PˆN complexes

SJ Roseblade, IG Smilović, Z Časar

Index: Roseblade, Stephen J.; Smilovic, Ivana Gazic; Casar, Zdenko Tetrahedron, 2014 , vol. 70, # 16 p. 2654 - 2660

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Citation Number: 2

Abstract

Abstract In this paper we report the first chemoselective asymmetric hydrogenation of (1- bromo-1-alkenyl) boronic esters, which constitutes a new route to (α-bromoalkyl) boronic esters. The study demonstrates that excellent chemoselectivities along with full conversions can be obtained for hydrogenation of alkyl substituted derivatives with iridium–PˆN complexes. Moreover, acyclic alkyl derivatives afford (α-bromoalkyl) boronic esters in ...