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Efficient and stereoselective synthesis of J-104,118, a novel, potent inhibitor of squalene synthase

Y Iwasawa, K Nonoshita, K Tomimoto

Index: Iwasawa, Yoshikazu; Nonoshita, Katsumasa; Tomimoto, Koji Tetrahedron Letters, 1995 , vol. 36, # 41 p. 7459 - 7462

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Citation Number: 11

Abstract

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... J-104,118, a novel and potent inhibitor of squalene synthase, was synthesized stereoselectively. The chiral amine 1 was efficiently synthesized by Sharpless asymmetric dihydroxylation as a key reaction. ... J-104,118, a novel, potent inhibitor of squalene synthase, was ...

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